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Claudin 25

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Protein-coding gene in the species Homo sapiens
CLDN25
Identifiers
AliasesCLDN25, claudin 25
External IDsHomoloGene: 19476; GeneCards: CLDN25; OMA:CLDN25 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)
Chromosome 11 (human)Genomic location for CLDN25Genomic location for CLDN25
Band11q23.2Start113,779,796 bp
End113,780,485 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • olfactory zone of nasal mucosa

  • anterior pituitary

  • skeletal muscle tissue

  • muscle of leg

  • gastrocnemius muscle
    n/a
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

644672

n/a

Ensembl

ENSG00000228607

n/a

UniProt

C9JDP6

n/a

RefSeq (mRNA)

NM_001101389

n/a

RefSeq (protein)

NP_001094859

n/a

Location (UCSC)Chr 11: 113.78 – 113.78 Mbn/a
PubMed searchn/a
Wikidata
View/Edit Human

Claudin 25 is a protein that in humans is encoded by the CLDN25 gene.

Function

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. .

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000228607 – Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: Claudin 25". Retrieved 2018-06-01.
  • 1. ^ ª GRCh38: Ensembl release 89: ENSG00000228607 – Ensembl, May 2017
  • 2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • 3. ^ "Entrez Gene: Claudin 25". Retrieved 2018-06-01.
  • 4. ^ Campbell M, Munnich A, Hashimoto Y (March 2024). “A loss of function mutation in CLDN25 causing Pelizaeus-Merzbacher-like leukodystrophy” Human Molecular Genetics, ddae038, PMID 38493358. DOI: 10.1093/hmg/ddae038. https://doi.org/10.1093/hmg/ddae038


Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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