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Cloprostenol

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Chemical compound Pharmaceutical compound
Cloprostenol
Clinical data
Trade namesCyclomate, Estrumate
Routes of
administration		Intramuscular
ATCvet code
Pharmacokinetic data
Excretion67% renal, 25% fecal
Identifiers
IUPAC name
  • (5Z)-7-{(1R,2R,3R,5S)-2--3,5-dihydroxycyclopentyl}-5-heptenoic acid
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.050.009 Edit this at Wikidata
Chemical and physical data
FormulaC22H29ClO6
Molar mass424.915
3D model (JSmol)
SMILES
  • c1cc(cc(c1)Cl)OC(/C=C/2(C(2C/C=C\CCCC(=O)O)O)O)O
InChI
  • InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1
  • Key:VJGGHXVGBSZVMZ-QIZQQNKQSA-N

Cloprostenol is a synthetic analogue of prostaglandin F2α (PGF2α). It is a potent luteolytic agent; this means that, within hours of administration, it causes the corpus luteum to stop production of progesterone, and to reduce in size over several days. This effect is used in animals to induce estrus and to cause abortion.

References

  1. ^ Cooper M (January 1981). "Prostaglandins in veterinary practice". In Practice. 3 (1): 30, 32–4. doi:10.1136/inpract.3.1.30. PMID 7346485. S2CID 6197103.
  2. Plumb DC (2015). "Cloprostenol Sodium". Plumb's Veterinary Drug Handbook (8th ed.). Wiley. ISBN 9781118911938.
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