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Complement receptor of the immunoglobulin family

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Protein family
V-set and immunoglobulin domain containing 4
Identifiers
SymbolVSIG4
NCBI gene11326
HGNC17032
OMIM300353
RefSeqNM_007268
UniProtQ9Y279
Other data
LocusChr. X q12-q13.3
Search for
StructuresSwiss-model
DomainsInterPro

Complement receptor of the immunoglobulin family is a protein expressed in Kupffer cells. It is a critical receptor for the phagocytosis of opsonised particles in the blood. It recognizes iC3b (inactivated C3b) deposited on microbial surfaces.

See also

References

  1. Helmy K, Katschke K, Gorgani N, Kljavin N, Elliott J, Diehl L, Scales S, Ghilardi N, van Lookeren Campagne M (2006). "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens". Cell. 124 (5): 915–27. doi:10.1016/j.cell.2005.12.039. PMID 16530040.
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