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Conjugated oligoelectrolytes, or COEs, are a class of synthetic antimicrobials designed to prevent and circumvent antimicrobial resistance via different mechanism of action than traditional antibiotics. COEs insert into cell membranes and can function as electron transporters, but were found to inhibit bacterial growth. They can also be used for tracking the progress of tumor growth.
References
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- Tiihonen, Armi; Cox-Vazquez, Sarah J.; Liang, Qiaohao; Ragab, Mohamed; Ren, Zekun; Hartono, Noor Titan Putri; Liu, Zhe; Sun, Shijing; Zhou, Cheng; Incandela, Nathan C.; Limwongyut, Jakkarin; Moreland, Alex S.; Jayavelu, Senthilnath; Bazan, Guillermo C.; Buonassisi, Tonio (17 November 2021). "Predicting Antimicrobial Activity of Conjugated Oligoelectrolyte Molecules via Machine Learning". Journal of the American Chemical Society. 143 (45): 18917–18931. arXiv:2105.10236. doi:10.1021/jacs.1c05055.
- Zhou, Cheng; Li, Zeshun; Zhu, Ziyue; Chia, Geraldine W. N.; Mikhailovsky, Alexander; Vázquez, Ricardo Javier; Chan, Samuel J. W.; Li, Kai; Liu, Bin; Bazan, Guillermo C. (May 2022). "Conjugated Oligoelectrolytes for Long‐Term Tumor Tracking with Incremental NIR‐II Emission". Advanced Materials. 34 (20): 2201989. doi:10.1002/adma.202201989.
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