| ctgf/hcs24 CAESAR | |
|---|---|
 Predicted secondary structure and sequence conservation of CAESAR | |
| Identifiers | |
| Symbol | CAESAR |
| Rfam | RF00172 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Eukaryota |
| SO | SO:0000233 |
| PDB structures | PDBe |
ctgf/hcs24 CAESAR is the name given to the cis-acting RNA element identified in the 3' untranslated region (3'UTR) of the human connective tissue growth factor (CTGF) messenger RNA. This gene is also known as hypertrophic chondrocyte specific 24 (hcs24).
The importance of the 3'UTR in repressing ctgf gene expression was initially characacterised and subsequently the minimal RNA element responsible for repression was identified This element was predicted to form a stable secondary structure, which acts as a post-transcriptional cis-acting element of structure-anchored repression (CAESAR).
The 3'UTR of the ctgf/hcs24 gene in chicken has also been shown to be involved in repression of gene expression.
References
- ^ Kubota S, Hattori T, Nakanishi T, Takigawa M (1999). "Involvement of cis-acting repressive element(s) in the 3'-untranslated region of human connective tissue growth factor gene". FEBS Lett. 450 (1–2): 84–88. doi:10.1016/S0014-5793(99)00480-9. PMID 10350062.
- Kubota S, Kondo S, Eguchi T, et al. (2000). "Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) gene: similarities to retroviral RNA-protein interactions". Oncogene. 19 (41): 4773–4786. doi:10.1038/sj.onc.1203835. PMID 11032028.
- Mukudai Y, Kubota S, Takigawa M (2003). "Conserved repressive regulation of connective tissue growth factor/hypertrophic chondrocyte-specific gene 24 (ctgf/hcs24) enabled by different elements and factors among vertebrate species". Biol. Chem. 384 (1): 1–9. doi:10.1515/BC.2003.001. PMID 12674494. S2CID 25685816.
External links
 | This molecular or cell biology article is a stub. You can help Misplaced Pages by expanding it. |