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In enzymology, a D-lysopine dehydrogenase (EC 1.5.1.16) is an enzyme that catalyzes the chemical reaction

N₂-(D-1-carboxyethyl)-L-lysine + NADP + H₂O ${\displaystyle \rightleftharpoons }$ L-lysine + pyruvate + NADPH + H

The 3 substrates of this enzyme are N2-(D-1-carboxyethyl)-L-lysine, NADP, and H₂O, whereas its 4 products are L-lysine, pyruvate, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming). Other names in common use include D-lysopine synthase, lysopine dehydrogenase, D(+)-lysopine dehydrogenase, 2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase, and (L-lysine-forming). This enzyme participates in lysine degradation.

References

• Otten LA, Vreugdenhil D, Schilperoort RA (1977). "Properties of D(+)-lysopine dehydrogenase from crown gall tumour tissue". Biochim. Biophys. Acta. 485 (2): 268–77. doi:10.1016/0005-2744(77)90163-2. PMID 21695.

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