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D12-methyl
Consensus secondary structure and sequence conservation of D12-methyl RNA
Identifiers
Symbol	D12-methyl
Rfam	RF02950
Other data
RNA type	Gene; sRNA
SO	SO:0001263
PDB structures	PDBe

The D12-methyl RNA motif is a conserved RNA structure that was discovered by bioinformatics. D12-methyl motifs are found in metagenomic DNA samples, and have not yet been found in a classified organism.

It is ambiguous whether D12-methyl RNAs function as cis-regulatory elements or whether they operate in trans. On the one hand, they are located upstream of protein-coding genes of a variety of types. This fact could suggest that D12-methyl RNAs function in cis. However, many of the associated genes are typical of those located in prophages. Since phage genomes often consist of a small number of large operons, it is possible that the D12-methyl RNAs are simply one of the genetic elements in a long, phage transcriptional unit.

References

1. Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.

• Non-coding RNA