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DAP (gene)

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Protein-coding gene in the species Homo sapiens
DAP
Identifiers
AliasesDAP, death associated protein
External IDsOMIM: 600954; MGI: 1918190; HomoloGene: 3235; GeneCards: DAP; OMA:DAP - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)
Chromosome 5 (human)Genomic location for DAPGenomic location for DAP
Band5p15.2Start10,679,230 bp
End10,761,234 bp
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)
Chromosome 15 (mouse)Genomic location for DAPGenomic location for DAP
Band15|15 B2Start31,224,460 bp
End31,274,487 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • stromal cell of endometrium

  • islet of Langerhans

  • gallbladder

  • right coronary artery

  • thoracic aorta

  • ascending aorta

  • left adrenal gland

  • right adrenal cortex

  • left adrenal cortex
Top expressed in
  • transitional epithelium of urinary bladder

  • calvaria

  • gastrula

  • blood

  • pyloric antrum

  • pancreas

  • islet of Langerhans

  • left lobe of liver

  • ankle

  • body of femur
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1611

223453

Ensembl

ENSG00000112977

ENSMUSG00000039168

UniProt

P51397

Q91XC8

RefSeq (mRNA)

NM_004394
NM_001291963

NM_146057

RefSeq (protein)

NP_001278892
NP_004385

NP_666169

Location (UCSC)Chr 5: 10.68 – 10.76 MbChr 15: 31.22 – 31.27 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Death-associated protein 1 is a protein that in humans is encoded by the DAP gene.

DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000112977Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000039168Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096.
  6. Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Feb 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes Dev. 9 (1): 15–30. doi:10.1101/gad.9.1.15. PMID 7828849.
  7. ^ "Entrez Gene: DAP death-associated protein".

Further reading


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