Misplaced Pages

DMWD
Identifiers
Aliases	DMWD, D19S593E, DMR-N9, DMRN9, gene59, dystrophia myotonica, WD repeat containing, DM1 locus, WD repeat containing
External IDs	OMIM: 609857; MGI: 94907; HomoloGene: 22559; GeneCards: DMWD; OMA:DMWD - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 45,782,947 bp End 45,792,845 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A3|7 9.46 cM Start 18,810,152 bp End 18,816,701 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart popliteal artery tibial arteries right auricle right coronary artery gastrocnemius muscle right frontal lobe body of uterus Descending thoracic aorta gastric mucosa Top expressed in Rostral migratory stream subiculum granulocyte dentate gyrus of hippocampal formation granule cell epithelium of lens superior frontal gyrus otic vesicle nucleus accumbens retinal pigment epithelium prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component nucleus dendrite cell projection perikaryon cellular component Biological process protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1762 13401 Ensembl ENSG00000185800 ENSMUSG00000030410 UniProt Q09019 Q08274 RefSeq (mRNA) NM_004943 NM_010058 NM_001374607 RefSeq (protein) NP_004934 NP_034188 NP_001361536 Location (UCSC) Chr 19: 45.78 – 45.79 Mb Chr 7: 18.81 – 18.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Dystrophia myotonica WD repeat-containing protein is a protein that in humans is encoded by the DMWD gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000185800 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030410 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jansen G, Mahadevan M, Amemiya C, Wormskamp N, Segers B, Hendriks W, O'Hoy K, Baird S, Sabourin L, Lennon G, et al. (Jun 1993). "Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs". Nat Genet. 1 (4): 261–6. doi:10.1038/ng0792-261. PMID 1302022. S2CID 26072532.
6. "Entrez Gene: DMWD dystrophia myotonica, WD repeat containing".

Further reading

• Groenen P, Wieringa B (1999). "Expanding complexity in myotonic dystrophy". BioEssays. 20 (11): 901–12. doi:10.1002/(SICI)1521-1878(199811)20:11<901::AID-BIES5>3.0.CO;2-0. PMID 9872056. S2CID 24160357.
• Wansink DG, Wieringa B (2004). "Transgenic mouse models for myotonic dystrophy type 1 (DM1)". Cytogenet. Genome Res. 100 (1–4): 230–42. doi:10.1159/000072859. PMID 14526185. S2CID 9981696.
• Jansen G, Bächner D, Coerwinkel M, et al. (1995). "Structural organization and developmental expression pattern of the mouse WD-repeat gene DMR-N9 immediately upstream of the myotonic dystrophy locus". Hum. Mol. Genet. 4 (5): 843–52. doi:10.1093/hmg/4.5.843. hdl:2066/21198. PMID 7633444.
• Shaw DJ, McCurrach M, Rundle SA, et al. (1994). "Genomic organization and transcriptional units at the myotonic dystrophy locus". Genomics. 18 (3): 673–9. doi:10.1016/S0888-7543(05)80372-6. PMID 7905855.
• Mahadevan MS, Amemiya C, Jansen G, et al. (1993). "Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene". Hum. Mol. Genet. 2 (3): 299–304. doi:10.1093/hmg/2.3.299. PMID 8499920.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Alwazzan M, Newman E, Hamshere MG, Brook JD (1999). "Myotonic dystrophy is associated with a reduced level of RNA from the DMWD allele adjacent to the expanded repeat". Hum. Mol. Genet. 8 (8): 1491–7. doi:10.1093/hmg/8.8.1491. PMID 10400997.
• Eriksson M, Hedberg B, Carey N, Ansved T (2001). "Decreased DMPK transcript levels in myotonic dystrophy 1 type IIA muscle fibers". Biochem. Biophys. Res. Commun. 286 (5): 1177–82. doi:10.1006/bbrc.2001.5516. PMID 11527424.
• Frisch R, Singleton KR, Moses PA, et al. (2001). "Effect of triplet repeat expansion on chromatin structure and expression of DMPK and neighboring genes, SIX5 and DMWD, in myotonic dystrophy". Mol. Genet. Metab. 74 (1–2): 281–91. doi:10.1006/mgme.2001.3229. PMID 11592825.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

This article on a gene on human chromosome 19 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 19
• Human chromosome 19 gene stubs