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DOTAM

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Organic compound used as a chelator
DOTAM
Names
IUPAC name 2-acetamide
Other names
  • TCMC
  • 2,2′,2”,2”’-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide
  • 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic amide
  • 1,4,7,10-tetraaza-1,4,7,10-tetra(2-carbamoylmethyl)cyclododecane
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
CompTox Dashboard (EPA)
InChI
  • Key: FQIHLPGWBOBPSG-UHFFFAOYSA-N
  • InChI=1S/C16H32N8O4/c17-13(25)9-21-1-2-22(10-14(18)26)5-6-24(12-16(20)28)8-7-23(4-3-21)11-15(19)27/h1-12H2,(H2,17,25)(H2,18,26)(H2,19,27)(H2,20,28)
SMILES
  • NC(CN1CCN(CC(N)=O)CCN(CC(N)=O)CCN(CC(N)=O)CC1)=O
Properties
Chemical formula C16H32N8O4
Molar mass 400.484 g·mol
Appearance White powder
Solubility in water Soluble (hygroscopic)
Hazards
GHS labelling:
Pictograms GHS07: Exclamation mark
Signal word Warning
Hazard statements H315, H319, H335
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

DOTAM (also known as TCMC) is an organic compound used as a chelator much like its carboxylic acid analog DOTA. A derivative with a reactive linking group of para-isothiocyanatobenzyl attached to the cyclen ring is also of interest as a bifunctional chelator (BFC).

p-SCN-Bn-DOTAM

References

  1. Brennecke, Benjamin; Wang, Qinghua; Haap, Wolfgang; Grether, Uwe; Hu, Hai-Yu; Nazaré, Marc (2021-04-21). "DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells". Bioconjugate Chemistry. 32 (4): 702–712. doi:10.1021/acs.bioconjchem.0c00699. ISSN 1043-1802. PMID 33691062. S2CID 232192471.
  2. Stenberg, Vilde Yuli; Larsen, Roy Hartvig; Ma, Li-Wei; Peng, Qian; Juzenas, Petras; Bruland, Øyvind Sverre; Juzeniene, Asta (January 2021). "Evaluation of the PSMA-Binding Ligand 212Pb-NG001 in Multicellular Tumour Spheroid and Mouse Models of Prostate Cancer". International Journal of Molecular Sciences. 22 (9): 4815. doi:10.3390/ijms22094815. PMC 8124365. PMID 34062920.
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