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DPEP3
Identifiers
Aliases	DPEP3, MBD3, dipeptidase 3
External IDs	OMIM: 609926; MGI: 1919104; HomoloGene: 23357; GeneCards: DPEP3; OMA:DPEP3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 67,975,663 bp End 67,980,549 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 106,700,145 bp End 106,706,061 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis gonad testicle sperm blood granulocyte spleen bone marrow muscle of thigh Top expressed in spermatocyte spermatid seminiferous tubule primary oocyte morula morula secondary oocyte blastocyst Gonadal ridge zygote More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity metalloexopeptidase activity dipeptidyl-peptidase activity metallopeptidase activity hydrolase activity metal ion binding dipeptidase activity Cellular component anchored component of membrane membrane acrosomal vesicle plasma membrane Biological process male meiotic nuclear division meiosis proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64180 71854 Ensembl ENSG00000141096 ENSMUSG00000031898 UniProt Q9H4B8 Q9DA79 RefSeq (mRNA) NM_022357 NM_001129758 NM_001370198 NM_027960 RefSeq (protein) NP_001123230 NP_001357127 NP_082236 Location (UCSC) Chr 16: 67.98 – 67.98 Mb Chr 8: 106.7 – 106.71 Mb PubMed search
Wikidata
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Dipeptidase 3 (DPEP3) is a protein that in humans is encoded by the DPEP3 gene.

This gene encodes a membrane-bound glycoprotein from the family of dipeptidases (EC 3.4.13.19) involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family, DPEP2. Alternatively spliced transcript variants that encode different isoforms have been found for this gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000141096 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000031898 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Habib GM, Shi ZZ, Cuevas AA, Lieberman MW (July 2003). "Identification of two additional members of the membrane-bound dipeptidase family". The FASEB Journal. 17 (10): 1313–5. doi:10.1096/fj.02-0899fje. PMID 12738806. S2CID 15252871.
6. "Entrez Gene: Dipeptidase 3".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Sabatti C, Service SK, Hartikainen AL, et al. (2009). "Genome-wide association analysis of metabolic traits in a birth cohort from a founder population". Nat. Genet. 41 (1): 35–46. doi:10.1038/ng.271. PMC 2687077. PMID 19060910.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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