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DTL
Identifiers
Aliases	DTL, CDT2, DCAF2, L2RAMP, denticleless E3 ubiquitin protein ligase homolog
External IDs	OMIM: 610617; MGI: 1924093; HomoloGene: 32313; GeneCards: DTL; OMA:DTL - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.3 Start 212,035,553 bp End 212,107,400 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H6 Start 191,269,468 bp End 191,307,656 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte trabecular bone embryo testicle ventricular zone bone marrow ganglionic eminence gonad bone marrow cells sperm Top expressed in mandibular prominence maxillary prominence zygote secondary oocyte ureter lumbar spinal ganglion primitive streak primary oocyte hand fetal liver hematopoietic progenitor cell More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding Cellular component centrosome nuclear membrane membrane chromosome microtubule organizing center nucleolus Cul4A-RING E3 ubiquitin ligase complex Cul4B-RING E3 ubiquitin ligase complex cytoskeleton nucleus nucleoplasm cytoplasm cytosol Cul4-RING E3 ubiquitin ligase complex Biological process ubiquitin-dependent protein catabolic process protein polyubiquitination protein monoubiquitination regulation of cell cycle DNA replication protein ubiquitination response to UV translesion synthesis post-translational protein modification cellular response to DNA damage stimulus positive regulation of G2/M transition of mitotic cell cycle positive regulation of protein catabolic process mitotic G2 DNA damage checkpoint signaling rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51514 76843 Ensembl ENSG00000143476 ENSMUSG00000037474 UniProt Q9NZJ0 Q3TLR7 RefSeq (mRNA) NM_001286229 NM_001286230 NM_016448 NM_029766 NM_001305233 RefSeq (protein) NP_001273158 NP_001273159 NP_057532 NP_001292162 NP_084042 Location (UCSC) Chr 1: 212.04 – 212.11 Mb Chr 1: 191.27 – 191.31 Mb PubMed search
Wikidata
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Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.

Interactions

DTL (gene) has been shown to interact with P21.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000143476 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000037474 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem. 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750.
6. "Entrez Gene: DTL denticleless homolog (Drosophila)".
7. Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. 22 (18): 2496–506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.

Further reading

• Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes". Cell Cycle. 5 (15): 1719–29. doi:10.4161/cc.5.15.3150. PMID 16861890.
• Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage". Cell Cycle. 5 (15): 1675–80. doi:10.4161/cc.5.15.3149. PMID 16861906.
• Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006). "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1". Mol. Cell. 23 (5): 709–21. doi:10.1016/j.molcel.2006.08.010. PMID 16949367.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. hdl:10397/34293. PMID 17041588. S2CID 22180568.
• Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA (2006). "DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint". Genes Dev. 20 (22): 3117–29. doi:10.1101/gad.1482106. PMC 1635147. PMID 17085480.
• Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC (2007). "Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma" (PDF). Cell Cycle. 5 (22): 2676–87. doi:10.4161/cc.5.22.3500. PMID 17106265.

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