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Dario Altieri

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Cancer researcher
Dario Carlo Altieri
Occupation(s)President and CEO

Dario Carlo Altieri, an Italian-born physician-scientist, is the president and CEO of The Wistar Institute in Philadelphia. He is also the holder of the Robert and Penny Fox Distinguished Professor and the director of the National Cancer Institute-designated Ellen and Ronald Caplan Cancer Center at The Wistar Institute.

Biography

Altieri was born in Milan, Italy, where he attended the University of Milan Medical School. He trained in internal medicine with a postgraduate specialty degree in clinical and experimental hematology. In 1987, he joined the Scripps Clinic and Research Foundation in La Jolla, California, as a research fellow before becoming a faculty member. In 1994, Altieri became an associate professor in the Department of Pathology, Boyer Center for Molecular Medicine at Yale University School of Medicine, and was promoted to full professor in 1999. In 2002, he became the founding Chair of the Department of Cancer Biology at the University of Massachusetts Medical School.

Research

His research has focused on Inhibitors of Apoptosis (IAP), a family of genes essential for proliferation and survival of cells. His work has identified survivin, one of these IAP genes, is over-produced in almost every human cancer, and his team is currently studying the biology of survivin and how it could be used to develop treatments for cancer.

Altieri has also been involved in the development of gamitrinib, a Hsp90 inhibitor that was shown to disable the activity of mitochondria in cancerous cells.

In 2013, Altieri and his team received a $1.5 million grant from the United States Department of Defense to prepare the drug for human trials. He also co-founded the Cancer Biology Training Consortium and the Pancreatic Cancer alliance in 2005.

Further reading

References

  1. ^ "Dario C. Altieri: Chief Executive Officer of Wistar Institute". The University of Pennsylvania. Retrieved 2 March 2015.
  2. "Cancer Biologist Dario Altieri to Lead the Wistar Institute Cancer Center". The Wistar Institute. Retrieved 11 February 2014.
  3. ^ "Biography Dario C. Altieri, MD.; Association of American Cancer Institutes".
  4. "Gene "survivin" inhibits cell death" (PDF). Yale Cancer Center. Retrieved 2023-03-15.
  5. "Dario C. Altieri, M.D." The Wistar Institute. Retrieved 28 January 2014.
  6. "Thrivin' (not just survivin') in Philadelphia". The Journal of Clinical Investigation. Retrieved 28 January 2014.
  7. "Emerging Research Fronts - 2009". ScienceWatch. Retrieved 11 February 2014.
  8. "Wistar Receives $1.5 Million Department of Defense Grant To Ready Potential Prostate Drug For Clinical Use". The Wistar Institute. Archived from the original on 22 February 2014. Retrieved 28 January 2014.
  9. "Combinatorial Drugs Target Cancer Cell Mitochonndria". biotechdaily.com. Retrieved 11 February 2014.
  10. "Cancer Biologist Dario Altieri to Lead the Wistar Institute Cancer Center". The Wistar Institute. Retrieved 28 January 2014.

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