TRNA pseudouridine38/39 synthase

tRNA pseudouridine synthase (EC 5.4.99.45, Deg1, Pus3p, pseudouridine synthase 3) is an enzyme with systematic name tRNA-uridine uracil mutase. This enzyme catalyses the following chemical reaction

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tRNA pseudouridine

The enzyme from Saccharomyces cerevisiae is active only towards uridine and uridine.

References

Lecointe F, Simos G, Sauer A, Hurt EC, Motorin Y, Grosjean H (January 1998). "Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop". The Journal of Biological Chemistry. 273 (3): 1316–23. doi:10.1074/jbc.273.3.1316. PMID 9430663.
Chen J, Patton JR (October 2000). "Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA". Biochemistry. 39 (41): 12723–30. doi:10.1021/bi001109m. PMID 11027153.

v t e Isomerase: mutases (EC 5.4)
5.4.1 Acyl Groups	Lysolecithin acylmutase Precorrin-8X methylmutase
5.4.2 Phosphomutases	Phosphoglycerate mutase Bisphosphoglycerate mutase Phosphoglucomutase Phosphomannomutase PMM1 PMM2 Phosphoenolpyruvate mutase
5.4.99 Other groups	Cycloartenol synthase Lanosterol synthase Lupeol synthase Methylmalonyl-CoA mutase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)