Dehaene is a surname. Notable people with the surname include:
- Stanislas Dehaene, a professor at the Collège de France
- Jean-Luc Dehaene, former Prime Minister of Belgium
- Luc Dehaene [nl], former mayor of Ypres
- Tom Dehaene [nl], Flemish politician, son of Jean-Luc Dehaene.
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