Desolation Island may refer to:
- Kerguelen Islands, Indian Ocean
- Desolación Island, Chile
- Desolation Island (South Shetland Islands)
- Desolation Island (novel), a novel by Patrick O'Brian
- Desolation Island (book), a Fiction Express book by Dan Smith
See also
- Desolation Sound, a deep water sound in British Columbia, Canada
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