Despain is a surname. Notable people with the surname include:
- Bree Despain (born 1979), American author
- Don G. Despain (1940–2022), American botanist, plant ecologist, and fire behavior specialist
- Dave Despain (born 1946), American motorsport journalist
- Michelle Despain (born 1984), Argentine-American luger
Surname listThis page lists people with the surname Despain. If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link. Category: