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Desu or DESU may refer to:

• Desu (Japanese: です), the polite form of the Japanese copula often translated as "to be"
  • Suiseiseki, a character from the anime and manga series Rozen Maiden whose overusage and unusual pronunciation of the copula became an early Internet meme
• Adalbert Deșu (Béla Dezső, 1909–1937), a Romanian football striker
• Delaware State University, sometimes abbreviated as DESU
• Diplôme d'études supérieures universitaires (DESU), a French academic grade

• Disambiguation pages