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Discrete papular lichen myxedematosus is a skin condition caused by fibroblasts producing abnormally large amounts of mucopolysaccharides characterized by the occurrence of waxy, flesh-colored papules..

Signs and symptoms

Discrete papular lichen myxedematosus is typically identified by the presence of violaceous, flesh-colored, or reddish, waxy papules that range in size from 2 to 5 mm and that symmetrically affect the trunk and limbs.

Causes

This disease's etiology is still unknown.

Diagnosis

Histologically, a normal epidermis is covered by a diffuse or focal mucinous deposit and edema in the upper and mid dermis. Although there isn't any sclerosis or collagen deposition, fibroblast proliferation varies.

Treatment

Numerous therapies have been attempted, with varying degrees of success, such as dermabrasion, CO2 laser, intralesional injections of corticosteroids or hyaluronidase, oral retinoids, psoralen ultraviolet A, and pimecrolimus. Given its ability to inhibit both tumor necrosis factor-a and transforming growth factor-b, thus decreasing the synthesis of glycosaminoglycans by fibroblasts, topical tacrolimus 0.1% has recently been proposed as an effective substitute.

See also

• Papular mucinosis
• List of cutaneous conditions

References

1. Rapini RP, Bolognia JL, Jorizzo JL (2007). Dermatology: 2-Volume Set (2nd ed.). St. Louis: Mosby. ISBN 978-1-4160-2999-1.
2. James WD, Berger TG, Elston DM, Neuhaus IM, Micheletti RG (2016). "Chapter 9: Mucinoses: Lichen Myxedematosus". Andrews' Diseases of the Skin: Clinical Dermatology (12th ed.). Philadelphia: Saunders Elsevier. pp. 179–182. ISBN 978-0-323-31967-6.
3. ^ Hadj I, Gallouj S, Meziane M, Mernissi FZ (2014). "Discrete papular lichen myxedematosus: a rare entity or an under- diagnosed disease?". The Pan African Medical Journal. 19: 180. doi:10.11604/pamj.2014.19.180.5389. PMC 4366121. PMID 25815101.
4. Rongioletti F, Rebora A (February 2001). "Updated classification of papular mucinosis, lichen myxedematosus, and scleromyxedema". Journal of the American Academy of Dermatology. 44 (2). Elsevier BV: 273–281. doi:10.1067/mjd.2001.111630. PMID 11174386.
5. Concheiro J, Pérez-Pérez L, Peteiro C, Labandeira J, Toribio J (December 2009). "Discrete papular lichen myxoedematosus: a rare subtype of cutaneous mucinosis". Clinical and Experimental Dermatology. 34 (8). Oxford University Press (OUP): e608 – e610. doi:10.1111/j.1365-2230.2009.03294.x. PMID 19486062. S2CID 20660876.
6. Rongioletti F, Zaccaria E, Cozzani E, Parodi A (March 2008). "Treatment of localized lichen myxedematosus of discrete type with tacrolimus ointment". Journal of the American Academy of Dermatology. 58 (3). Elsevier BV: 530–532. doi:10.1016/j.jaad.2006.10.021. PMID 18280368.

External links

• Mucinoses