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| DmpG-like communication domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate | |||||||||
| Identifiers | |||||||||
| Symbol | DmpG_comm | ||||||||
| Pfam | PF07836 | ||||||||
| InterPro | IPR012425 | ||||||||
| SCOP2 | 1nvm / SCOPe / SUPFAM | ||||||||
| |||||||||
In molecular biology, the DmpG-like communication domain is a protein domain found towards the C-terminal region of various aldolase enzymes. It consists of five alpha-helices, four of which form an antiparallel helical bundle that plugs the C terminus of the N-terminal TIM barrel domain. The communication domain is thought to play an important role in the heterodimerisation of the enzyme.
This domain heterodimerises with acetaldehyde dehydrogenases to form a bifunctional aldolase-dehydrogenase.
References
- ^ Manjasetty BA, Powlowski J, Vrielink A (June 2003). "Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate". Proc. Natl. Acad. Sci. U.S.A. 100 (12): 6992–7. doi:10.1073/pnas.1236794100. PMC 165818. PMID 12764229.