Misplaced Pages

DOCK6
Identifiers
Aliases	DOCK6, AOS2, ZIR1, Dock6, dedicator of cytokinesis 6
External IDs	OMIM: 614194; MGI: 1914789; HomoloGene: 83291; GeneCards: DOCK6; OMA:DOCK6 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 11,199,295 bp End 11,262,524 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A3 Start 21,711,156 bp End 21,763,931 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon right lung apex of heart upper lobe of left lung left lobe of thyroid gland right lobe of thyroid gland skin of leg skin of abdomen subcutaneous adipose tissue gastric mucosa Top expressed in interventricular septum tail of embryo lip ascending aorta left lung semi-lunar valve aortic valve left lung lobe internal carotid artery muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function guanyl-nucleotide exchange factor activity Cellular component perinuclear region of cytoplasm cytoplasm cytosol Biological process small GTPase mediated signal transduction blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57572 319899 Ensembl ENSG00000130158 ENSMUSG00000032198 UniProt Q96HP0 Q8VDR9 RefSeq (mRNA) NM_020812 NM_001367830 NM_177030 RefSeq (protein) NP_065863 NP_001354759 NP_796004 Location (UCSC) Chr 19: 11.2 – 11.26 Mb Chr 9: 21.71 – 21.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Dedicator of cytokinesis protein 6 (Dock6), also known as Zir1 is a large (~200 kDa) protein encoded in the human by the DOCK6 gene, involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G-proteins.

Discovery

Dock6 was identified as one of a family of proteins which share high sequence similarity with Dock180, the archetypal member of the DOCK family. It has a similar domain arrangement to other DOCK proteins, with a DHR1 domain known in other proteins to bind phospholipids, and a DHR2 domain containing the GEF activity.

Function

There is currently very little information about the cellular role of this protein. However, Dock6 has been reported to exhibit dual GEF specificity towards the small G proteins Rac1 and Cdc42. It is the only DOCK family member reported to activate both of these G proteins. The same study also showed that transfection of the Dock6 DHR2 domain into N1E-115 neuroblastoma cells promoted Rac- and Cdc42-dependent neurite outgrowth, although the physiological significance of this has yet to be demonstrated.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000130158 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032198 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez gene: DOCK6 dedicator of cytokinesis 6".
6. Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell Sci. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077.
7. Meller N, Merlot S, Guda C (November 2005). "CZH proteins: a new family of Rho-GEFs". J. Cell Sci. 118 (Pt 21): 4937–46. doi:10.1242/jcs.02671. PMID 16254241.
8. Côté JF, Motoyama AB, Bush JA, Vuori K (August 2005). "A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signaling". Nat. Cell Biol. 7 (8): 797–807. doi:10.1038/ncb1280. PMC 1352170. PMID 16025104.
9. Côté JF, Vuori K (2006). "In Vitro Guanine Nucleotide Exchange Activity of DHR-2/DOCKER/CZH2 Domains". Regulators and Effectors of Small GTPases: Rho Family. Methods in Enzymology. Vol. 406. pp. 41–57. doi:10.1016/S0076-6879(06)06004-6. ISBN 978-0-12-182811-0. PMID 16472648.
10. Miyamoto Y, Yamauchi J, Sanbe A, Tanoue A (February 2007). "Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth". Exp. Cell Res. 313 (4): 791–804. doi:10.1016/j.yexcr.2006.11.017. PMID 17196961.

Further reading

• Côté JF, Vuori K (2007). "GEF what? Dock180 and related proteins help Rac to polarize cells in new ways". Trends Cell Biol. 17 (8): 383–93. doi:10.1016/j.tcb.2007.05.001. PMC 2887429. PMID 17765544.
• Kwofie MA, Skowronski J (2008). "Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors". J. Biol. Chem. 283 (6): 3088–96. doi:10.1074/jbc.M705170200. PMID 18056264.
• Katoh H, Negishi M (2003). "RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo". Nature. 424 (6947): 461–64. Bibcode:2003Natur.424..461K. doi:10.1038/nature01817. PMID 12879077. S2CID 4411133.

This article on a gene on human chromosome 19 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 19
• Human chromosome 19 gene stubs