Domecq is a Spanish family name. It may refer to:
- Allied Domecq, a former British wine and spirits company
- Álvaro Domecq y Díez, fighter pilot, bullfighting promoter and member of the Spanish sherry family
- Juan Domecq, a former basketball player from Cuba
- Alcina Lubitch Domecq, a Jewish Guatemalan short story writer
- H. Bustos Domecq, a pseudonym used for several collaborative works by the Argentine writers Jorge Luis Borges and Adolfo Bioy Casares.
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