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Drug discrimination (DD) is a technique in behavioral neuroscience used to evaluate the discriminative stimulus properties of psychoactive drugs. The discriminative stimulus properties of drugs are believed to reflect their subjective effects. When partial or full stimulus generalization of a test drug to a training drug occurs, the test drug can be assumed to have effects that are subjectively similar to those of the training drug. Drug discrimination tests are usually performed in animals, but have also been conducted in humans. Drug discrimination assays have been employed to assess whether drugs have hallucinogen- or entactogen-like effects, among many other types of drug effects.

See also

• Head-twitch response

References

1. ^ Porter JH, Prus AJ, Overton DA (2018). "Drug Discrimination: Historical Origins, Important Concepts, and Principles". Curr Top Behav Neurosci. Current Topics in Behavioral Neurosciences. 39: 3–26. doi:10.1007/7854_2018_40. ISBN 978-3-319-98559-6. PMID 29637526.
2. ^ Young, Richard (2009). "Drug Discrimination". Methods of Behavior Analysis in Neuroscience. Boca Raton (FL): CRC Press/Taylor & Francis. ISBN 978-1-4200-5234-3. PMID 21204332. Retrieved 1 November 2024.
3. Colpaert FC (October 1999). "Drug discrimination in neurobiology". Pharmacol Biochem Behav. 64 (2): 337–345. doi:10.1016/s0091-3057(99)00047-7. PMID 10515310.
4. Stolerman, I.P. (1993). "Drug discrimination". Techniques in the Behavioral and Neural Sciences. Vol. 10. Elsevier. pp. 217–243. doi:10.1016/b978-0-444-81444-9.50014-6. ISBN 978-0-444-81444-9. ISSN 0921-0709.
5. Bolin BL, Alcorn JL, Reynolds AR, Lile JA, Rush CR (August 2016). "Human drug discrimination: A primer and methodological review". Exp Clin Psychopharmacol. 24 (4): 214–228. doi:10.1037/pha0000077. PMC 4965187. PMID 27454673.
6. Bolin BL, Alcorn JL, Reynolds AR, Lile JA, Stoops WW, Rush CR (2018). "Human Drug Discrimination: Elucidating the Neuropharmacology of Commonly Abused Illicit Drugs". Curr Top Behav Neurosci. Current Topics in Behavioral Neurosciences. 39: 261–295. doi:10.1007/7854_2016_10. ISBN 978-3-319-98559-6. PMC 5461212. PMID 27272070.
7. Baker LE (2018). "Hallucinogens in Drug Discrimination". Curr Top Behav Neurosci. Current Topics in Behavioral Neurosciences. 36: 201–219. doi:10.1007/7854_2017_476. ISBN 978-3-662-55878-2. PMID 28484970.
8. Winter JC (April 2009). "Hallucinogens as discriminative stimuli in animals: LSD, phenethylamines, and tryptamines". Psychopharmacology (Berl). 203 (2): 251–263. doi:10.1007/s00213-008-1356-8. PMID 18979087.
9. Mori T, Suzuki T (2018). "The Discriminative Stimulus Properties of Hallucinogenic and Dissociative Anesthetic Drugs". Curr Top Behav Neurosci. Current Topics in Behavioral Neurosciences. 39: 141–152. doi:10.1007/7854_2016_29. ISBN 978-3-319-98559-6. PMID 27586539.

Further reading

• Glennon, R.A.; Young, R. (2011). Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies. Wiley. ISBN 978-0-470-43352-2. Retrieved 2 November 2024.

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