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Dupee is a surname. Notable people with the surname include:

• Caroline Dupee Wade (1857–1947), American painter
• Dave Dupee (1916–2008), American professional basketball player
• F. W. Dupee (1904–1979), American literary critic
• Frank Dupee (1877–1956), American baseball player
• George Washington Dupee (1826–1897), American slave-turned-Baptist leader
• Kenneth Dupee Swan (1887–1970), American photographer
• Leonard Dupee White (1891–1958), American historian
• Michael George Dupée (born 1966), American game show contestant and author

• Surnames