ERCC may refer to:
- East Riding County Council, Yorkshire, England
- Early Rain Covenant Church, Chengdu, Sichuan, China, a Presbyterian church
- Edinburgh Rape Crisis Centre, Scotland, a charity
- Edinburgh Regional Computing Centre
- Directorate-General for European Civil Protection and Humanitarian Aid Operations ยง Emergency Response Coordination Centre (ERCC)
- European Rugby Champions Cup, Europe's top rugby union club competition
- European Rugby Challenge Cup, the second tier competition
- Evangelical Reformed Church of Christ, Nigeria
- Excision repair cross-complementing, including a list of ERCC genes
- External RNA Controls Consortium; see Epitranscriptomic sequencing
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