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EXTL3
Identifiers
Aliases	EXTL3, BOTV, EXTL1L, EXTR1, REGR, RPR, exostosin like glycosyltransferase 3, ISDNA
External IDs	OMIM: 605744; MGI: 1860765; HomoloGene: 1103; GeneCards: EXTL3; OMA:EXTL3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.1 Start 28,600,469 bp End 28,756,561 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D1 Start 65,289,509 bp End 65,387,304 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ventricular zone ganglionic eminence islet of Langerhans prefrontal cortex gastric mucosa frontal pole apex of heart Brodmann area 10 right auricle Top expressed in aortic valve perirhinal cortex ascending aorta nucleus of stria terminalis internal carotid artery external carotid artery renal corpuscle piriform cortex entorhinal cortex atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity metal ion binding glycosyltransferase activity Cellular component integral component of membrane membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus Biological process positive regulation of cell growth IRE1-mediated unfolded protein response heparan sulfate proteoglycan biosynthetic process protein glycosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2137 54616 Ensembl ENSG00000012232 ENSMUSG00000021978 UniProt O43909 Q9WVL6 Q6P1H4 RefSeq (mRNA) NM_001440 NM_018788 NM_001360385 RefSeq (protein) NP_001431 NP_061258 NP_001347314 NP_001391867 NP_001391868 NP_001391869 NP_001391870 NP_001391871 NP_001391872 NP_001391873 NP_001391874 NP_001391875 Location (UCSC) Chr 8: 28.6 – 28.76 Mb Chr 14: 65.29 – 65.39 Mb PubMed search
Wikidata
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Exostosin-like 3 is a protein that in humans is encoded by the EXTL3 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000012232 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000021978 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Van Hul W, Wuyts W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Bossuyt P, Willems PJ (Apr 1998). "Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family". Genomics. 47 (2): 230–7. doi:10.1006/geno.1997.5101. PMID 9479495.
6. Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.
7. Mizuno K, Irie S, Sato TA (Mar 2001). "Overexpression of EXTL3/EXTR1 enhances NF-kappaB activity induced by TNF-alpha". Cell Signal. 13 (2): 125–30. doi:10.1016/S0898-6568(00)00144-3. PMID 11257457.
8. "Entrez Gene: EXTL3 exostoses (multiple)-like 3".

Further reading

• Saito T, Seki N, Yamauchi M, et al. (1998). "Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family". Biochem. Biophys. Res. Commun. 243 (1): 61–6. doi:10.1006/bbrc.1997.8062. PMID 9473480.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• McCormick C, Duncan G, Goutsos KT, Tufaro F (2000). "The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 668–73. Bibcode:2000PNAS...97..668M. doi:10.1073/pnas.97.2.668. PMC 15388. PMID 10639137.
• Kobayashi S, Akiyama T, Nata K, et al. (2000). "Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor". J. Biol. Chem. 275 (15): 10723–6. doi:10.1074/jbc.275.15.10723. PMID 10753861.
• Kim BT, Kitagawa H, Tamura Ji J, et al. (2002). "Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation". J. Biol. Chem. 277 (16): 13659–65. doi:10.1074/jbc.M111630200. PMID 11832488.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bishnupuri KS, Luo Q, Korzenik JR, et al. (2007). "Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes". Cancer Biol. Ther. 5 (12): 1714–20. doi:10.4161/cbt.5.12.3469. PMID 17106246.

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