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El Sakkakini (Arabic: السكاكيني) is a small district (quarter) in Cairo, Egypt that neighbours the El Zaher and Abbaseya districts.
El Sakkakini was originally part of El Zaher, but it was named after a huge building built by a prominent French architect, and was owned by the head of the Syrian Skakkini family, Count Gabriel Habib Sakkakini Pasha (1841–1923), consisting of a palace and a church in the same area in 1897. In addition, Sakkakini Pasha, is known to have established the Roman Catholic Patriarchate in Faggala and the Roman Catholic Cemetery in Old Cairo.