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ELMOD2
Identifiers
Aliases	ELMOD2, 9830169G11Rik, ELMO domain containing 2
External IDs	OMIM: 610196; MGI: 2445165; HomoloGene: 16662; GeneCards: ELMOD2; OMA:ELMOD2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q31.1 Start 140,524,168 bp End 140,553,770 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C2 Start 84,039,261 bp End 84,059,115 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon mucosa of ileum renal medulla lateral nuclear group of thalamus spinal ganglia cardia trigeminal ganglion mucosa of paranasal sinus jejunal mucosa nasal epithelium Top expressed in primary oocyte otic vesicle secondary oocyte zygote otolith organ utricle Epithelium of choroid plexus hand retinal pigment epithelium medullary collecting duct More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity Cellular component membrane Biological process defense response to virus regulation of defense response to virus positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 255520 244548 Ensembl ENSG00000179387 ENSMUSG00000035151 UniProt Q8IZ81 Q8BGF6 RefSeq (mRNA) NM_153702 NM_001170691 NM_178736 RefSeq (protein) NP_714913 NP_001164162 NP_848851 Location (UCSC) Chr 4: 140.52 – 140.55 Mb Chr 8: 84.04 – 84.06 Mb PubMed search
Wikidata
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ELMO domain containing 2 is a protein that in humans is encoded by the ELMOD2 gene.

Function

This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000179387 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000035151 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ELMO domain containing 2". Retrieved 2016-08-29.

Further reading

• Hodgson U, Pulkkinen V, Dixon M, Peyrard-Janvid M, Rehn M, Lahermo P, Ollikainen V, Salmenkivi K, Kinnula V, Kere J, Tukiainen P, Laitinen T (2006). "ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis". Am. J. Hum. Genet. 79 (1): 149–54. doi:10.1086/504639. PMC 1474126. PMID 16773575.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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