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Enarodustat

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Chemical compound Pharmaceutical compound
Enarodustat
Clinical data
Trade namesEnaroy
Other namesJTZ-951
Legal status
Legal status
  • Rx-only (Japan)
Identifiers
IUPAC name
  • 2-{triazolopyridin-8-yl]formamido}acetic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC17H16N4O4
Molar mass340.339 g·mol
3D model (JSmol)
SMILES
  • C1=CC=C(C=C1)CCC2=CC(=O)C(=C3N2NC=N3)C(=O)NCC(=O)O
InChI
  • InChI=1S/C17H16N4O4/c22-13-8-12(7-6-11-4-2-1-3-5-11)21-16(19-10-20-21)15(13)17(25)18-9-14(23)24/h1-5,8,10H,6-7,9H2,(H,18,25)(H,19,20)(H,23,24)
  • Key:FJYRBJKWDXVHHO-UHFFFAOYSA-N

Enarodustat (development code JTZ-951; brand name Enaroy) is a drug used for the treatment of anemia, especially when associated with chronic kidney disease (CKD). Enarodustat functions as a inhibitor of hypoxia inducible factor-proly hydroxylase (HIF-PH).

The drug was approved in September 2020 in Japan for anemia associated with CKD and is currently in clinical development in the United States and South Korea. The drug is being developed by Japan Tobacco and JW Pharmaceutical.

References

  1. Hirota K (April 2021). "HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review". Biomedicines. 9 (5): 468. doi:10.3390/biomedicines9050468. PMC 8146675. PMID 33923349.
  2. "JT Receives Manufacturing and Marketing Approval of ENAROY Tablets 2mg･4mg for the Treatment of Anemia Associated with Chronic Kidney Disease in Japan" (PDF) (Press release). September 25, 2020.
  3. Markham A (January 2021). "Enarodustat: First Approval". Drugs. 81 (1): 169–174. doi:10.1007/s40265-020-01444-3. PMID 33320297. S2CID 229163684.
  4. "Enarodustat - Japan Tobacco". Adis Insight.
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