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In enzymology, an ephedrine dehydrogenase (EC 1.5.1.18) is an enzyme that catalyzes the chemical reaction

(-)-ephedrine + NAD ${\displaystyle \rightleftharpoons }$ (R)-2-methylimino-1-phenylpropan-1-ol + NADH + H

Thus, the two substrates of this enzyme are (-)-ephedrine and NAD, whereas its 3 products are (R)-2-methylimino-1-phenylpropan-1-ol, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (-)-ephedrine:NAD+ 2-oxidoreductase.

References

• Klamann E, Lingens F (1980). "Degradation of (-)-ephedrine by Pseudomonas putida. Detection of (-)-ephedrine: NAD+-oxidoreductase from Arthrobacter globiformis". Z. Naturforsch. C. 35 (1–2): 80–7. PMID 7405363.

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