Epsiprantel - Misplaced Pages

Chemical compound Pharmaceutical compound

Epsiprantel
Clinical data

Trade names	Cestex
Other names	BRL 38705
Routes of administration	By mouth
ATCvet code	QP52AA04 (WHO) QP52AA54 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	Minimal
Identifiers
IUPAC name 2-(Cyclohexylcarbonyl)-2,3,6,7,8,12b-hexahydropyrazino benzazepin-4(1H)-one
CAS Number	98123-83-2
PubChem CID	72026
ChemSpider	65020
UNII	0C1SPQ0FSR
ChEMBL	ChEMBL64979
CompTox Dashboard (EPA)	DTXSID3057858
Chemical and physical data
Formula	C₂₀H₂₆N₂O₂
Molar mass	326.440 g·mol
3D model (JSmol)	Interactive image
SMILES O=C4N2C(c1c(cccc1)CCC2)CN(C(=O)C3CCCCC3)C4
InChI InChI=1S/C20H26N2O2/c23-19-14-21(20(24)16-8-2-1-3-9-16)13-18-17-11-5-4-7-15(17)10-6-12-22(18)19/h4-5,7,11,16,18H,1-3,6,8-10,12-14H2 Key:LGUDKOQUWIHXOV-UHFFFAOYSA-N

Epsiprantel (trade name Cestex) is a veterinary drug which is used as an anthelmintic against tapeworms such as Echinococcus granulosus.

Indications

It is indicated for the removal of cestodes (tapeworms) in cats (Dipylidium caninum and Taenia taeniaeformis) and dogs (Dipylidium caninum and Taenia pisiformis) 7 weeks of age and older.

^ "Cestex (epsiprantel) Veterinary Tablets. Prescribing Information" (PDF). Zoetis Inc. Kalamazoo, MI 49007. Retrieved 2 October 2016.
Arru E, Garippa G, Manger BR (November 1990). "Efficacy of epsiprantel against Echinococcus granulosus infections in dogs". Research in Veterinary Science. 49 (3): 378–9. doi:10.1016/0034-5288(90)90080-N. PMID 2267429.

Binds tubulin	benzimidazole Triclabendazole
AChE inhibitor	phosphonic acid Metrifonate
Other/unknown	quinoline Arpraziquantel Praziquantel (+esafoxolaner/eprinomectin) Oxamniquine phenol Bithionol thiazole Niridazole thioxanthone Hycanthone Lucanthone antimony compounds Stibophen Tartar emetic

Binds tubulin	benzimidazole Albendazole
Other/unknown	quinoline Praziquantel (+esafoxolaner/eprinomectin) salicylanilide Niclosamide aminoacridine Quinacrine butyrophenone Desaspidin chlorophenol Dichlorophen

Binds tubulin	benzimidazole Mebendazole Albendazole Tiabendazole Fenbendazole Ciclobendazole Flubendazole
Glutamate-gated chloride channel, GABA receptor	avermectins Abamectin Doramectin Emamectin Eprinomectin (+esafoxolaner/praziquantel) Ivermectin Selamectin milbemycins Moxidectin (+fluralaner) Milbemycin oxime
NMDA	tetrahydropyrimidine Pyrantel pyrantel pamoate Oxantel Morantel Carbantel Febantel (aka felsantel)
Other/unknown	piperazine Piperazine Diethylcarbamazine thiazole Levamisole quinolinium Pyrvinium benzylammonium Bephenium naphthalenesulfonate Suramin Ascaridole Hexylresorcinol Santonin Tribendimidine Tetrachloroethylene

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