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| Epstein–Barr virus nuclear-antigen (EBNA) internal ribosome entry site (IRES) | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES EBNA | |
| Identifiers | |
| Symbol | IRES_EBNA |
| Rfam | RF00448 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Viruses |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
The Epstein–Barr virus nuclear-antigen internal ribosome entry site (EBNA IRES) is an internal ribosome entry site (IRES) that is found in an exon in the 5' untranslated region of the Epstein–Barr virus nuclear antigen 1 (EBNA1) gene. The EBNA IRES allows EBNA1 translation to occur under situations where initiation from the 5' cap structure and ribosome scanning is reduced. It is thought that the EBNA IRES is necessary for the regulation of latent-gene expression.
The EBNA IRES is located in the U leader exon, which is a portion of the mRNA of the Epstein–Barr virus common to all four EBNA1 transcripts.
See also
References
- ^ Isaksson A, Berggren M, Ricksten A (January 2003). "Epstein-Barr virus U leader exon contains an internal ribosome entry site". Oncogene. 22 (4): 572–581. doi:10.1038/sj.onc.1206149. PMID 12555070.
External links
- Page for IRES_EBNA at Rfam
- Page for Human herpesvirus 1 small nucleolar RNA at Rfam
- Page for EBER1 at Rfam
- Page for v-snoRNA1 at Rfam