Esca can refer to:
- The esca or illicium, a modified luminescent fin ray found in anglerfish
- Esca (grape disease)
- the Ezka, a river in the Basque country known as "Esca" in Spanish
- ESCA or Electron Spectroscopy for Chemical Analysis, now known as X-ray photoelectron spectroscopy (XPS)
- ESCA - The famous actor Holden Hickson, who uses ESCA as a nickname
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