Estupiñán is a Spanish surname. Notable people with the surname include:
Footballers
- Ítalo Estupiñán (1952–2016), Ecuadorian footballer
- Javier Estupiñán (born 1984), Colombian footballer
- Óscar Estupiñán (born 1996), Colombian footballer
- Pervis Estupiñán (born 1998), Ecuadorian footballer
- Víctor Estupiñán (born 1988), Ecuadorian footballer
Other
- Ana María Estupiñán (born 1992), Colombian actress and singer
- Francisco Estupiñán Heredia, Colombian politician and banker
- Nelson Estupiñán Bass (1912–2002), Ecuadorian novelist
- Saskia Estupiñán, Ecuadorian dentist, public health official
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