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FANCD2OS

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Protein-coding gene in the species Homo sapiens
FANCD2OS
Identifiers
AliasesFANCD2OS, C3orf24, FANCD2 opposite strand
External IDsMGI: 1918229; HomoloGene: 45456; GeneCards: FANCD2OS; OMA:FANCD2OS - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)
Chromosome 3 (human)Genomic location for FANCD2OSGenomic location for FANCD2OS
Band3p25.3Start10,081,317 bp
End10,108,255 bp
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)
Chromosome 6 (mouse)Genomic location for FANCD2OSGenomic location for FANCD2OS
Band6|6 E3Start113,573,722 bp
End113,577,676 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • pancreatic ductal cell

  • sperm

  • testicle

  • gonad

  • muscle tissue

  • granulocyte

  • minor salivary glands

  • gastric mucosa
Top expressed in
  • seminiferous tubule

  • spermatid

  • proximal tubule

  • morula

  • embryo

  • right kidney

  • human kidney

  • spermatocyte

  • blastocyst

  • blastocyst
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

115795

70979

Ensembl

ENSG00000163705

ENSMUSG00000033963

UniProt

Q96PS1

Q9D4K4

RefSeq (mRNA)

NM_173472
NM_001164839

NM_027633

RefSeq (protein)

NP_001158311
NP_775743

NP_081909

Location (UCSC)Chr 3: 10.08 – 10.11 MbChr 6: 113.57 – 113.58 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Fanconi Anemia Opposite Strand Transcript protein is a predicted protein that in humans is encoded by the FANCD2OS gene. The name is derived from mRNA transcribed from the strand complementary to the FANCD2 gene.

Gene

The gene is encoded on Chromosome 3 (human) at p25.3 on the minus strand from 10081320-10108339nt. The primary transcript is 1105nt which codes for a protein of 177 amino acid in length. The gene on the strand complementary to FANCD2 located 5' from CYCSP11 and 3’ from BRK1 and VHL genes.

mRNA

There are six alternatively spliced transcripts with differences in the 5' and 3' ends as well changes in exon usage. The most common isoform is 1105 bp.

Promoter Region

The promoter region predicted by the Genomatix El Dorado algorithm spans from 10108742-10108009 bp. Promoters are associated with a wide variety of tissues including B-lymphocytes, germ cells, muscle, neurons & prostate.

Regulatory

Secondary structure of the 5’ UTR sequence conserved between humans and gibbon contain sequence recognized by to RBMX, Ras & Rab proteins. The sequence for the secondary structure of the 3’ UTR are recognized by EIF4B and RBMX.

Expression

FANCD2OS is moderately expressed in the human brain, placenta and testes.

Evolutionary History

Protein sequence

The protein from the longest transcript is 177AA in length with a mass of 20188.59kD. The protein consists of a domain of unknown function from the DUF4563 superfamily.

Orthologs

Orthologs of FANCD2OS exist throughout mammals, reptiles, birds and in the cartilaginous fish Australian ghostshark. The protein sequence undergoes mutation at a rate similar to the blood protein fibrinogen.

Species Common name NCBI accession Identity similarity E-value
Pongo abelii Sumatran orangutan XP_003776240.1 98.9 99.4 1.21E-133
Cricetulus griseus Chinese hamster XP_003511850.1 73.6 80.9 1.56E-95
Ovis aries Sheep XP_004018322.1 97.2 98.3 6.79E-131
Leptonychotes weddellii Weddell seal XP_006739055.1 96.6 98.3 5.13E-130
Condylura cristata Star-nosed mole XP_004692437.1 91.0 95.5 3.01E-123
Orcinus orca Killer whale XP_004286877.2 88.1 92.3 1.05E-90
Trichechus manatus latirostris Florida manatee XP_004368376.1 96.6 98.9 9.95E-131
Alligator mississippiensis American alligator XP_014457972.1 69.3 88.6 1.40E-48
Chrysemys picta bellii Painted turtle XP_005307285.1 58.3 75 2.18E-78
Gekko japonicus Schlegel's Japanese gecko XP_015261231.1 56.5 72.3 4.39E-74
Thamnophis sirtalis Common garter snake XP_013914711.1 55.9 69.5 2.75E-69
Xenopus laevis African clawed frog NP_001088778.1 55.4 71.2 1.98E-68
Xenopus tropicalis Western clawed frog NP_001090717.1 52 71.2 3.57E-65
Callorhinchus milii Australian ghostshark XP_007888744.1 39.9 56.8 5.67E-43

Paralogs

FANCD2OS has no known paralogs in Homo sapiens.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000163705 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000033963 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene - FANCD2OS FANCD2 opposite strand Homo sapiens". Retrieved 6 February 2016.
  6. ^ "FANCD2 opposite strand protein". NCBI. Retrieved 2 May 2016.
  7. ^ "AceView C3orf24". NCBI. Retrieved 2 May 2016.
  8. "Homo sapiens FANCD2 opposite strand (FANCD2OS), transcript variant 1, mRNA". NCBI Nucleotide. NCBI. Retrieved 19 April 2016.
  9. ^ "NCBI - GDS592 / gnf1m17159_at / Fancd2os". NCBI. Retrieved 15 Mar 2016.
  10. ^ "Conserved Protein Domain Family DUF4563". NCBI. Retrieved 2 May 2016.
  11. ^ "Homologene: FANCD2OS". Retrieved 6 February 2016.
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