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FBXW10

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Protein-coding gene in the species Homo sapiens
FBXW10
Identifiers
AliasesFBXW10, Fbw10, HREP, SM25H2, SM2SH2, F-box and WD repeat domain containing 10
External IDsOMIM: 611679; MGI: 3052463; HomoloGene: 32757; GeneCards: FBXW10; OMA:FBXW10 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for FBXW10Genomic location for FBXW10
Band17p11.2Start18,744,026 bp
End18,779,349 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for FBXW10Genomic location for FBXW10
Band11|11 B2Start62,737,895 bp
End62,768,291 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • left testis

  • right testis

  • olfactory zone of nasal mucosa

  • right uterine tube

  • right adrenal cortex

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • right lobe of liver

  • gastrocnemius muscle
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • embryo

  • zygote

  • secondary oocyte

  • embryo

  • thymus

  • primary oocyte

  • visual cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10517

213980

Ensembl

ENSG00000171931

ENSMUSG00000090173

UniProt

Q5XX13

Q5SUS0

RefSeq (mRNA)

NM_001267585
NM_001267586
NM_031456

NM_001033669
NM_001291441

RefSeq (protein)

NP_001254514
NP_001254515

NP_001028841
NP_001278370
NP_001391704
NP_001391705
NP_001391706

NP_001391707

Location (UCSC)Chr 17: 18.74 – 18.78 MbChr 11: 62.74 – 62.77 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.

Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004). Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID 20498703).


References

  1. ^ GRCh38: Ensembl release 89: ENSG00000171931 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000090173 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kennerson ML, Nassif NT, Nicholson GA (Dec 1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics. 53 (1): 110–2. doi:10.1006/geno.1998.5453. PMID 9787083.
  6. Kennerson ML, Gordon MJ, Blair IP, Nicholson GA (Dec 1995). "Single test for two hereditary neuropathies, CMT1A and HNPP". Clin Chem. 41 (10): 1534–5. doi:10.1093/clinchem/41.10.1534. PMID 7586531.
  7. ^ "Entrez Gene: FBXW10 F-box and WD repeat domain containing 10".

Further reading

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