In histopathology, feathery degeneration, formally feathery degeneration of hepatocytes, is a form of liver parenchymal cell (i.e. hepatocyte) death associated with cholestasis.
Cells undergoing this form of cell death have a flocculant appearing cytoplasm, and are larger than normal hepatocytes.
Relation to ballooning degeneration
Feathery degeneration is somewhat similar in appearance to ballooning degeneration, which is due to other causes (e.g. alcohol, obesity); it also has cytoplasmic clearing and cell swelling.
See also
- Elevated alkaline phosphatase (ALP)
- Mallory body
- Non-alcoholic fatty liver disease
- Steatohepatitis
- Primary sclerosing cholangitis
Additional images
-
Feathery degeneration. H&E stain.
References
- Desmet, VJ (1995). "Histopathology of cholestasis". Verh Dtsch Ges Pathol. 79: 233–40. PMID 8600686.
- Li, MK; Crawford, JM (Feb 2004). "The pathology of cholestasis". Semin Liver Dis. 24 (1): 21–42. doi:10.1055/s-2004-823099. PMID 15085484.
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