Misplaced Pages

Fenoverine

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Chemical compound
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.
Find sources: "Fenoverine" – news · newspapers · books · scholar · JSTOR (May 2021) (Learn how and when to remove this message)
You can help expand this article with text translated from the corresponding article in Italian. (May 2014) Click for important translation instructions.
  • Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Misplaced Pages.
  • Consider adding a topic to this template: there are already 805 articles in the main category, and specifying|topic= will aid in categorization.
  • Do not translate text that appears unreliable or low-quality. If possible, verify the text with references provided in the foreign-language article.
  • You must provide copyright attribution in the edit summary accompanying your translation by providing an interlanguage link to the source of your translation. A model attribution edit summary is Content in this edit is translated from the existing Italian Misplaced Pages article at ]; see its history for attribution.
  • You may also add the template {{Translated|it|Fenoverina}} to the talk page.
  • For more guidance, see Misplaced Pages:Translation.
Pharmaceutical compound
Fenoverine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • 2-dioxol-5-ylmethyl)piperazin-1-yl]-1-(10H-phenothiazin-10-yl)ethanone
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.048.666 Edit this at Wikidata
Chemical and physical data
FormulaC26H15N3O3S
Molar mass449.48 g·mol
3D model (JSmol)
SMILES
  • C1CN(CCN1CC2=CC3=C(C=C2)OCO3)CC(=O)N4C5=CC=CC=C5SC6=CC=CC=C64
InChI
  • InChI=1S/C26H25N3O3S/c30-26(29-20-5-1-3-7-24(20)33-25-8-4-2-6-21(25)29)17-28-13-11-27(12-14-28)16-19-9-10-22-23(15-19)32-18-31-22/h1-10,15H,11-14,16-18H2
  • Key:UBAJTZKNDCEGKL-UHFFFAOYSA-N
  (verify)

Fenoverine (INN) is an antispasmodic drug, which acts by inhibiting calcium channels . In the case of Fenoverine, the relaxation occurs in abdominal / intestinal smooth muscles, while in case of antianginal drugs, the relaxation occurs in coronary vessels. Notably Fenoverine does not act as an antianginal agent.

Toxicity

Fenoverine is known to cause rhabdomyolysis.

References

  1. Martínez-Vázquez MA, Vázquez-Elizondo G, González-González JA, Gutiérrez-Udave R, Maldonado-Garza HJ, Bosques-Padilla FJ (2012). "Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: systematic review and meta-analysis". Revista de Gastroenterologia de Mexico. 77 (2): 82–90. doi:10.1016/j.rgmx.2012.04.002. PMID 22672854.
  2. ^ Chariot P, Ratiney R, Le Maguet F, Fourestié V, Astier A, Gherardi R (August 1995). "Fenoverine-induced rhabdomyolysis". Hum Exp Toxicol. 14 (8): 654–656. doi:10.1177/096032719501400805. PMID 7576832.
  3. Cho J, Na J, Bae E, Lee TW, Jang HN, Cho HS, Chang SH, Park DJ (April 2020). "The incidence, risk factors, and clinical outcomes of rhabdomyolysis associated with fenoverine prescription: a retrospective study in South Korea (1999-2014)". BMC Pharmacol Toxicol. 21 (1): 30. doi:10.1186/s40360-020-00408-3. PMC 7183697. PMID 32334639.
Drugs for functional gastrointestinal disorders (A03)
Drugs for
functional
bowel
disorders
Antimuscarinics
Tertiary
amino group
Quaternary
ammonium
compounds
Phosphodiesterase
inhibitors
Acting on
serotonin receptors
Other
Belladonna
and derivatives
(antimuscarinics)
Propulsives


Stub icon

This drug article relating to the gastrointestinal system is a stub. You can help Misplaced Pages by expanding it.

Categories: