Francesco d'Este may refer to:
- Francesco d'Este (14th century) (?–1312), son of Obizzo II, brother of Azzo VIII d'Este, of Aldobrandino and Fresco d'Este
- Francesco d'Este (1325–1384), son of Bertoldo I d'Este
- Francesco d'Este (1516–1578) son of Alfonso I d'Este and Lucrezia Borgia
- Francesco I d'Este, Duke of Modena (1610–1658), son of Alfonso III d'Este
- Francesco II d'Este, Duke of Modena (1660–1694), son of Alfonso IV d'Este
- Francesco III d'Este, Duke of Modena (1698–1780), son of Rinaldo d'Este
- Francis IV, Duke of Modena (1779–1886), son of Ferdinand Karl, Archduke of Austria–Este
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