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FREM1
Identifiers
Aliases	FREM1, BNAR, C9orf143, C9orf145, C9orf154, MOTA, TILRR, TRIGNO2, FRAS1 related extracellular matrix 1
External IDs	OMIM: 608944; MGI: 2670972; HomoloGene: 27049; GeneCards: FREM1; OMA:FREM1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p22.3 Start 14,737,152 bp End 14,910,995 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 C3 Start 82,816,157 bp End 82,970,576 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in smooth muscle tissue metanephros body of uterus right hemisphere of cerebellum Descending thoracic aorta ascending aorta body of pancreas popliteal artery tibial arteries right coronary artery Top expressed in left lung lobe Epithelium of choroid plexus otolith organ utricle vas deferens Gonadal ridge retinal pigment epithelium vestibular membrane of cochlear duct ciliary body dermis More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding carbohydrate binding Cellular component integral component of membrane extracellular region basement membrane Biological process multicellular organism development cell communication cell-matrix adhesion cell adhesion craniofacial suture morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 158326 329872 Ensembl ENSG00000164946 ENSMUSG00000059049 UniProt Q5H8C1 Q684R7 RefSeq (mRNA) NM_001177704 NM_144966 NM_001370058 NM_001370060 NM_001370061 NM_001370063 NM_001370065 NM_001379081 NM_001198811 NM_177863 RefSeq (protein) NP_001171175 NP_659403 NP_001356987 NP_001356989 NP_001356990 NP_001356992 NP_001356994 NP_001366010 NP_001185740 NP_808531 Location (UCSC) Chr 9: 14.74 – 14.91 Mb Chr 4: 82.82 – 82.97 Mb PubMed search
Wikidata
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FRAS1-related extracellular matrix protein 1 is a protein that in humans is encoded by the FREM1 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000164946 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000059049 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
6. Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ (Sep 2004). "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proc Natl Acad Sci U S A. 101 (37): 13560–5. Bibcode:2004PNAS..10113560S. doi:10.1073/pnas.0402760101. PMC 518794. PMID 15345741.
7. "Entrez Gene: FREM1 FRAS1 related extracellular matrix 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kiyozumi D, Osada A, Sugimoto N, et al. (2005). "Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle". Exp. Cell Res. 306 (1): 9–23. doi:10.1016/j.yexcr.2005.01.020. PMID 15878328.

External links

• GeneReviews/NCBI/NIH/UW entry on Manitoba Oculotrichoanal Syndrome, Marles Syndrome, MOTA Syndrome

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