Misplaced Pages

In enzymology, a γ-glutamylhistamine synthase (EC 6.3.2.18) is an enzyme that catalyzes the chemical reaction

ATP + L-glutamate + histamine ${\displaystyle \rightleftharpoons }$ products of ATP breakdown + N-γ-L-glutamylhistamine

The 3 substrates of this enzyme are ATP, L-glutamate, and histamine, whereas its two products are products of ATP breakdown and Nalpha-gamma-L-glutamylhistamine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-glutamate:histamine ligase. Other names in common use include gamma-glutaminylhistamine synthetase, and gamma-GHA synthetase.

References

• Stein C, Weinreich D (1982). "An in vitro characterization of gamma-glutamylhistamine synthetase: a novel enzyme catalyzing histamine metabolism in the central nervous system of the marine mollusk, Aplysia californica". J. Neurochem. 38 (1): 204–14. doi:10.1111/j.1471-4159.1982.tb10873.x. PMID 6125565.

• Biology

• v
• t
• e

• EC 6.3.2
• Enzymes of unknown structure
• Ligase stubs