GAS5 - Misplaced Pages

Non-coding RNA in the species Homo sapiens

GAS5

Identifiers

GAS5, NCRNA00030, SNHG2, growth arrest specific 5 (non-protein coding)

External IDs

OMIM: 608280; GeneCards: GAS5; OMA:GAS5 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q25.1	Start	173,863,900 bp
Band	1q25.1	End	173,868,882 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

left ovary

body of pancreas

right ovary

cartilage tissue

right uterine tube

canal of the cervix

skin of abdomen

ganglionic eminence

skin of arm

body of uterus

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More reference expression data

BioGPS

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Orthologs

Species

Human

Mouse

Entrez


60674


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Ensembl


ENSG00000234741


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UniProt


n a


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RefSeq (mRNA)


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RefSeq (protein)


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Location (UCSC)

Chr 1: 173.86 – 173.87 Mb

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PubMed search

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Wikidata

View/Edit Human

Growth arrest-specific 5 is a non-protein coding RNA that in humans is encoded by the GAS5 gene.

GAS5 noncoding RNA, which accumulates in growth arrested cells, acts as a decoy hormone response element for the glucocorticoid receptor (GR) and hence blocks the upregulation of gene expression by activated GR.

A number of studies have linked GAS5 to apoptosis and it may play a role in the progression of some types of cancer.

The GAS5 introns host several snoRNA sequences, including SNORD81, SNORD47, SNORD80, SNORD79, SNORD78, SNORD44, SNORD77, SNORD76, SNORD75 and SNORD74. These intronic sequences are more conserved than the exons of the host gene, these sorts of genes are often called "inside-out genes".

It was recently discovered that the nonsense-mediated degradation pathway can regulate the function of the GAS5 in mammalian cells.

References

^ GRCh38: Ensembl release 89: ENSG00000234741 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: growth arrest-specific 5 (non-protein coding)".
^ Smith CM, Steitz JA (December 1998). "Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes". Molecular and Cellular Biology. 18 (12): 6897–6909. doi:10.1128/mcb.18.12.6897. PMC 109273. PMID 9819378.
Kino T, Hurt DE, Ichijo T, Nader N, Chrousos GP (2010). "Noncoding RNA Gas5 Is a Growth Arrest and Starvation-Associated Repressor of the Glucocorticoid Receptor". Sci Signal. 3 (107): ra8. doi:10.1126/scisignal.2000568. PMC 2819218. PMID 20124551.
Garabedian MJ, Logan SK (2010). "Glucocorticoid receptor DNA binding decoy is a gas". Sci Signal. 3 (108): pe5. doi:10.1126/scisignal.3108pe5. PMID 20145207. S2CID 21089519.
Mourtada-Maarabouni M, Pickard MR, Hedge VL, Farzaneh F, Williams GT (2009). "GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer". Oncogene. 28 (2): 195–208. doi:10.1038/onc.2008.373. PMID 18836484. S2CID 9209496.
Nakamura Y, Takahashi N, Kakegawa E, Yoshida K, Ito Y, Kayano H, Niitsu N, Jinnai I, Bessho M (2008). "The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma". Cancer Genet Cytogenet. 182 (2): 144–9. doi:10.1016/j.cancergencyto.2008.01.013. PMID 18406879.
Mourtada-Maarabouni M, Hedge VL, Kirkham L, Farzaneh F, Williams GT (2008). "Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5)". J Cell Sci. 121 (Pt 7): 939–46. doi:10.1242/jcs.024646. PMID 18354083. S2CID 218512.
Tanaka R, Satoh H, Moriyama M, Satoh K, Morishita Y, Yoshida S, Watanabe T, Nakamura Y, Mori S (2000). "Intronic U50 small-nucleolar-RNA (snoRNA) host gene of no protein-coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B-cell lymphoma". Genes Cells. 5 (4): 277–87. doi:10.1046/j.1365-2443.2000.00325.x. PMID 10792466.
Raho G, Barone V, Rossi D, Philipson L, Sorrentino V (2000). "The gas 5 gene shows four alternative splicing patterns without coding for a protein". Gene. 256 (1–2): 13–7. doi:10.1016/S0378-1119(00)00363-2. PMID 11054530.
Hirose T, Steitz JA (2001). "Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells". Proc. Natl. Acad. Sci. U.S.A. 98 (23): 12914–9. Bibcode:2001PNAS...9812914H. doi:10.1073/pnas.231490998. PMC 60799. PMID 11606788.
Eddy SR (1999). "Noncoding RNA genes". Current Opinion in Genetics & Development. 9 (6): 695–9. doi:10.1016/S0959-437X(99)00022-2. PMID 10607607.
Tani H, Torimura M, Akimitsu N (2013). "The RNA degradation pathway regulates the function of GAS5 a non-coding RNA in mammalian cells". PLOS ONE. 8 (1): e556884. Bibcode:2013PLoSO...855684T. doi:10.1371/journal.pone.0055684. PMC 3559549. PMID 23383264.

References

Further reading