Misplaced Pages

GemOx

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
(Redirected from GEMOX)

GemOx or GEMOX is an acronym for one of the chemotherapy regimens used in the treatment of relapsed or primary refractory non-Hodgkin's lymphoma and Hodgkin's lymphoma.

When combined with Rituximab it is called R-GemOx, R-GEMOX or GemOx-R, GEMOX-R.

The -GemOx regimen consists of:

  1. (R)ituximab - anti-CD20 monoclonal antibody that has the ability to kill both normal and malignant B cells;
  2. (Gem)citabine - an antimetabolite;
  3. (Ox)aliplatin - a platinum-based alkylating antineoplastic agent.

Dosing regimen

Drug Dose Mode Days
(R)ituximab 375 mg/m IV infusion Day 1
(Gem)citabine 1000 mg/m IV infusion in 500 ml normal saline with the speed of 10 mg/m/min Day 2
(Ox)aliplatin 100 mg/m IV infusion over 2hrs Day 2

References

  1. GEMOX-R regimen is a highly effective salvage regimen in patients with refractory / relapsing diffuse large-cell lymphoma: a phase II study
  2. Rituximab, gemcitabine and oxaliplatin: an effective salvage regimen for patients with relapsed or refractory B-cell lymphoma not candidates for high-dose therapy
Category: