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GGT7
Identifiers
Aliases	GGT7, D20S101, GGT4, GGTL3, GGTL5, dJ18C9.2, gamma-glutamyltransferase 7
External IDs	OMIM: 612342; MGI: 1913385; HomoloGene: 70866; GeneCards: GGT7; OMA:GGT7 - orthologs
EC number	3.4.19.13
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.22 Start 34,844,720 bp End 34,872,856 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H1 Start 155,490,379 bp End 155,518,237 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior pituitary apex of heart right frontal lobe right lobe of thyroid gland Brodmann area 9 left lobe of thyroid gland gastrocnemius muscle olfactory zone of nasal mucosa gastric mucosa Top expressed in nasal epithelium olfactory epithelium superior frontal gyrus primary visual cortex cerebellar cortex lateral geniculate nucleus medial dorsal nucleus medial geniculate nucleus pontine nuclei dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glutathione hydrolase activity acyltransferase activity protein binding hydrolase activity hypoglycin A gamma-glutamyl transpeptidase activity leukotriene C4 gamma-glutamyl transferase activity peptidyltransferase activity Cellular component integral component of membrane membrane plasma membrane Biological process glutathione biosynthetic process proteolysis glutathione catabolic process glutathione metabolic process leukotriene D4 biosynthetic process negative regulation of response to oxidative stress protein biosynthesis cellular amino acid metabolic process glutamate metabolic process cysteine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2686 207182 Ensembl ENSG00000131067 ENSMUSG00000027603 UniProt Q9UJ14 Q99JP7 RefSeq (mRNA) NM_178026 NM_001351702 NM_178025 NM_144786 NM_001362898 NM_001362900 RefSeq (protein) NP_821158 NP_001338631 NP_821158.2 NP_659035 NP_001349827 NP_001349829 Location (UCSC) Chr 20: 34.84 – 34.87 Mb Chr 2: 155.49 – 155.52 Mb PubMed search
Wikidata
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Gamma-glutamyltransferase 7 is an enzyme that in humans is encoded by the GGT7 gene.

Function

Gamma-glutamyltransferase is a membrane-associated protein involved in both glutathione metabolism and the transpeptidation of amino acids. Changes in gamma-glutamyltransferase activity may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene is similar in sequence to gamma-glutamyltransferase, but its function is unknown.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000131067 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000027603 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Figlewicz DA, Delattre O, Guellaen G, Krizus A, Thomas G, Zucman J, Rouleau GA (August 1993). "Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes". Genomics. 17 (2): 299–305. doi:10.1006/geno.1993.1325. PMID 8104871.
6. Heisterkamp N, Groffen J, Warburton D, Sneddon TP (May 2008). "The human gamma-glutamyltransferase gene family". Human Genetics. 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469. S2CID 15916758.
7. ^ "Entrez Gene: GGTL3 gamma-glutamyltransferase-like 3".

Further reading

• Jikuya H, Takano J, Kikuno R, Hirosawa M, Nagase T, Nomura N, Ohara O (February 2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones". DNA Research. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
• Llamazares M, Cal S, Quesada V, López-Otín C (April 2003). "Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain". The Journal of Biological Chemistry. 278 (15): 13382–9. doi:10.1074/jbc.M211900200. PMC 6066313. PMID 12562771.
• He X, Di Y, Li J, Xie Y, Tang Y, Zhang F, Wei L, Zhang Y, Qin W, Huo K, Li Y, Wan D, Gu J (September 2002). "Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism". Biochemical and Biophysical Research Communications. 297 (3): 528–36. doi:10.1016/S0006-291X(02)02227-1. PMID 12270127.

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