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GGT5
Identifiers
Aliases	GGT5, GGT-REL, GGTLA1, GGL, GGT 5, gamma-glutamyltransferase 5
External IDs	OMIM: 137168; MGI: 1346063; HomoloGene: 55802; GeneCards: GGT5; OMA:GGT5 - orthologs
EC number	3.4.19.14
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.23 Start 24,219,654 bp End 24,245,108 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 75,425,174 bp End 75,453,034 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland right coronary artery left lobe of thyroid gland left coronary artery left uterine tube canal of the cervix right auricle gastric mucosa tibial nerve subcutaneous adipose tissue Top expressed in granulocyte stroma of bone marrow gastrula uterus cervix muscle of thigh mammary gland lactiferous gland decidua mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity peptidase activity acyltransferase activity hydrolase activity leukotriene-C(4) hydrolase glutathione hydrolase activity hypoglycin A gamma-glutamyl transpeptidase activity peptidyltransferase activity leukotriene C4 gamma-glutamyl transferase activity Cellular component plasma membrane membrane integral component of membrane intrinsic component of plasma membrane Biological process leukotriene metabolic process glutathione biosynthetic process inflammatory response proteolysis cellular amino acid metabolic process glutathione metabolic process glutathione catabolic process leukotriene biosynthetic process leukotriene D4 biosynthetic process fatty acid metabolic process protein biosynthesis glutamate metabolic process cysteine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2687 23887 Ensembl ENSG00000099998 ENSMUSG00000006344 UniProt P36269 Q9Z2A9 RefSeq (mRNA) NM_001099781 NM_001099782 NM_001302464 NM_001302465 NM_004121 NM_011820 NM_001359425 RefSeq (protein) NP_001093251 NP_001093252 NP_001289393 NP_001289394 NP_004112 NP_035950 NP_001346354 Location (UCSC) Chr 22: 24.22 – 24.25 Mb Chr 10: 75.43 – 75.45 Mb PubMed search
Wikidata
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Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene.

Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4). The enzyme encoded by GGTLA1 is related to, but distinct from, gamma-glutamyl transpeptidase (GGT). The GGTLA1 enzyme consists of a heavy and a light chain and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay GGT. Its amino acid sequence shows an overall similarity of 39.5% with human GGT.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000099998 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000006344 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Heisterkamp N, Rajpert-De Meyts E, Uribe L, Forman HJ, Groffen J (Aug 1991). "Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase". Proc Natl Acad Sci U S A. 88 (14): 6303–7. Bibcode:1991PNAS...88.6303H. doi:10.1073/pnas.88.14.6303. PMC 52071. PMID 1676842.
6. Morris C, Courtay C, Geurts van Kessel A, ten Hoeve J, Heisterkamp N, Groffen J (Apr 1993). "Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22". Hum Genet. 91 (1): 31–6. doi:10.1007/bf00230218. PMID 8095916. S2CID 21440198.
7. Heisterkamp N, Groffen J, Warburton D, Sneddon TP (Apr 2008). "The human gamma-glutamyltransferase gene family". Hum Genet. 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469. S2CID 15916758.
8. ^ "Entrez Gene: GGTLA1 gamma-glutamyltransferase-like activity 1".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Enoiu M, Aberkane H, Salazar JF, et al. (2000). "Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme". Free Radic. Biol. Med. 29 (9): 825–33. doi:10.1016/S0891-5849(00)00370-1. PMID 11063908.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Edelmann L, Pandita RK, Morrow BE (2000). "Low-copy repeats mediate the common 3-Mb deletion in patients with velo-cardio-facial syndrome". Am. J. Hum. Genet. 64 (4): 1076–86. doi:10.1086/302343. PMC 1377832. PMID 10090893.
• Potdar PD, Andrews KL, Nettesheim P, Ostrowski LE (1997). "Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells". Am. J. Physiol. 273 (5 Pt 1): L1082–9. doi:10.1152/ajplung.1997.273.5.L1082. PMID 9374738.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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