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NOP53
Identifiers
Aliases	NOP53, PICT-1, PICT1, GLTSCR2, glioma tumor suppressor candidate region gene 2, NOP53 ribosome biogenesis factor
External IDs	OMIM: 605691; MGI: 2154441; HomoloGene: 44130; GeneCards: NOP53; OMA:NOP53 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 47,745,546 bp End 47,757,058 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 8.64 cM|7 A2 Start 15,670,108 bp End 15,679,999 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary body of pancreas right ovary skin of arm skin of leg ganglionic eminence skin of abdomen canal of the cervix body of uterus right uterine tube Top expressed in neural layer of retina ventricular zone yolk sac lip transitional epithelium of urinary bladder muscle of thigh esophagus genital tubercle molar granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding 5S rRNA binding protein binding p53 binding identical protein binding Cellular component intracellular anatomical structure intracellular membrane-bounded organelle nucleus nucleolus cytosol fibrillar center rDNA heterochromatin nucleoplasm Biological process ribosomal large subunit assembly regulation of protein phosphorylation protein stabilization regulation of signal transduction by p53 class mediator negative regulation of signal transduction by p53 class mediator regulation of aerobic respiration ribosomal large subunit export from nucleus negative regulation of transcription by RNA polymerase II DNA repair mitotic G2 DNA damage checkpoint signaling negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of protein-containing complex assembly negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of apoptotic process regulation of cell cycle cellular response to hypoxia protein localization to nucleolus protein localization to nucleoplasm cellular response to DNA damage stimulus regulation of RIG-I signaling pathway negative regulation of protein kinase B signaling negative regulation of transcription of nucleolar large rRNA by RNA polymerase I positive regulation of protein K63-linked deubiquitination ribosome biogenesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29997 68077 Ensembl ENSG00000105373 ENSMUSG00000041560 UniProt Q9NZM5 Q8BK35 RefSeq (mRNA) NM_015710 NM_133831 RefSeq (protein) NP_056525 NP_598592 Location (UCSC) Chr 19: 47.75 – 47.76 Mb Chr 7: 15.67 – 15.68 Mb PubMed search
Wikidata
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Glioma tumor suppressor candidate region gene 2 protein is a protein that in humans is encoded by the GLTSCR2 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000105373 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000041560 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN, Jenkins RB (Jun 2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.
6. Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y, Maehama T (Oct 2006). "Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation". Mol Biol Cell. 17 (11): 4888–95. doi:10.1091/mbc.E06-04-0301. PMC 1635402. PMID 16971513.
7. Yim JH, Kim YJ, Ko JH, Cho YE, Kim SM, Kim JY, Lee S, Park JH (Oct 2007). "The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death". Cell Death Differ. 14 (11): 1872–9. doi:10.1038/sj.cdd.4402204. PMID 17657248.
8. "Entrez Gene: GLTSCR2 glioma tumor suppressor candidate region gene 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bruni R, Fineschi B, Ogle WO, Roizman B (1999). "A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection". J. Virol. 73 (5): 3810–7. doi:10.1128/JVI.73.5.3810-3817.1999. PMC 104158. PMID 10196275.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Okahara F, Ikawa H, Kanaho Y, Maehama T (2004). "Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein". J. Biol. Chem. 279 (44): 45300–3. doi:10.1074/jbc.C400377200. PMID 15355975.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Yim JH, Kim YJ, Cho YE, et al. (2007). "GLTSCR2 sensitizes cells to hypoxic injury without involvement of mitochondrial apoptotic cascades". Pathobiology. 74 (5): 301–8. doi:10.1159/000105813. PMID 17890897.

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