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GPHA2
Identifiers
Aliases	GPHA2, A2, GPA2, ZSIG51, glycoprotein hormone alpha 2, glycoprotein hormone subunit alpha 2
External IDs	OMIM: 609651; MGI: 2156541; HomoloGene: 15605; GeneCards: GPHA2; OMA:GPHA2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 64,934,471 bp End 64,935,893 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 6,276,410 bp End 6,277,798 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte body of pancreas gonad gallbladder secondary oocyte testicle right testis Pituitary Gland left testis anterior pituitary Top expressed in adrenal gland morula blastocyst embryo zone of skin embryo lip urinary bladder ovary testicle More reference expression data BioGPS n/a
Gene ontology Molecular function hormone activity thyrotropin-releasing hormone receptor binding protein heterodimerization activity protein binding hormone receptor binding Cellular component extracellular region intracellular anatomical structure extracellular space Biological process cell surface receptor signaling pathway regulation of signaling receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 170589 170458 Ensembl ENSG00000149735 ENSMUSG00000024784 UniProt Q96T91 Q925Q5 RefSeq (mRNA) NM_130769 NM_130453 RefSeq (protein) NP_570125 NP_569720 Location (UCSC) Chr 11: 64.93 – 64.94 Mb Chr 19: 6.28 – 6.28 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Glycoprotein hormone alpha-2 is a protein that in humans is encoded by the GPHA2 gene.

GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002). (Supplied by OMIM.)

References

1. ^ GRCh38: Ensembl release 89: ENSG00000149735 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000024784 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ (Jan 2002). "Activation of orphan receptors by the hormone relaxin". Science. 295 (5555): 671–4. Bibcode:2002Sci...295..671H. doi:10.1126/science.1065654. PMID 11809971. S2CID 32693420.
6. ^ "Entrez Gene: GPHA2 glycoprotein hormone alpha 2".

7. Z. Gong, W. Wang, K. El Omari, A. A. Lebedev, O. B. Clarke, W. A. Hendrickson, Crystal structure of LGR ligand alpha2/beta5 from Caenorhabditis elegans with implications for the evolution of glycoprotein hormones. Proc Natl Acad Sci U S A 120 (1), e2218630120 (2023). https://www.pnas.org/doi/10.1073/pnas.2218630120#

Further reading

• Suzuki C, Nagasaki H, Okajima Y, et al. (2007). "The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin". Regul. Pept. 142 (1–2): 60–7. doi:10.1016/j.regpep.2007.01.009. PMID 17363077. S2CID 24382046.
• Breous E, Wenzel A, Loos U (2006). "Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit". Mol. Cell. Endocrinol. 245 (1–2): 169–80. doi:10.1016/j.mce.2005.11.009. PMID 16376481. S2CID 21211666.
• Sudo S, Kuwabara Y, Park JI, et al. (2005). "Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5". Endocrinology. 146 (8): 3596–604. doi:10.1210/en.2005-0317. PMID 15890769.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hsu SY, Nakabayashi K, Bhalla A (2003). "Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5". Mol. Endocrinol. 16 (7): 1538–51. doi:10.1210/mend.16.7.0871. PMID 12089349.
• Nakabayashi K, Matsumi H, Bhalla A, et al. (2002). "Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor". J. Clin. Invest. 109 (11): 1445–52. doi:10.1172/JCI14340. PMC 150994. PMID 12045258.

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