GSK 299423 - Misplaced Pages

GSK 299423
Names


Preferred IUPAC name 6-Methoxy-4-oxathiolopyridin-6-yl)methyl]amino}piperidin-1-yl)ethyl]quinoline-3-carbonitrile
Identifiers
CAS Number	1352149-24-6
3D model (JSmol)	Interactive image
ChemSpider	24751852
PubChem CID	46835136
UNII	2Q0G81H7FK
CompTox Dashboard (EPA)	DTXSID50159279
InChI InChI=1S/C25H27N5O2S/c1-31-20-2-3-23-22(11-20)21(17(12-26)13-29-23)6-9-30-7-4-18(5-8-30)27-14-19-10-25-24(15-28-19)32-16-33-25/h2-3,10-11,13,15,18,27H,4-9,14,16H2,1H3Key: NKXJSCXEAVZSMF-UHFFFAOYSA-N
SMILES COc1ccc2c(c1)c(c(cn2)C#N)CCN3CCC(CC3)NCc4cc5c(cn4)OCS5
Properties
Chemical formula	C₂₅H₂₇N₅O₂S
Molar mass	461.58 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is ?) Infobox references

Chemical compound

GSK 299423 or GlaxoSmithKline 299423 is an antibiotic chemical compound that has been identified as potentially effective in treating patients infected with bacteria expressing the New Delhi metallo-beta-lactamase. The antibiotic inhibits the enzyme topoisomerase, which bacteria need to replicate.

No animal studies have been reported. No application has been made for human clinical trials.

References

Sten Stovall, "Glaxo:New Compound Offers Way To Fight Drug-Resistant Bacteria," The Wall Street Journal, August 4, 2010
Melly Alazraki, "GlaxoSmithKline Finds Compound That Could Help Fight 'Superbugs' Archived 2010-08-16 at the Wayback Machine" Daily Finance, August 6, 2010
Bax BD, et al. (4 August 2010). "Type IIA topoisomerase inhibition by a new class of antibacterial agents". Nature. 466 (7309): 935–40. Bibcode:2010Natur.466..935B. doi:10.1038/nature09197. PMID 20686482. S2CID 205221405. (primary source)

Microbiology: Bacteria

Medical
microbiology

Biochemistry
and ecology

Oxygen preference	Aerobic Obligate Facultative Anaerobic Facultative Obligate Microaerophile Nanaerobe Aerotolerant
Other	Extremophile Human microbiome Gut Lung Mouth Skin Vaginal (in pregnancy) Placental Uterine Salivary Microbial metabolism Nitrogen fixation Microbial ecology Primary nutritional groups Substrate preference Lipophilic Saccharophilic

Shape

Structure

Cell envelope	Cell membrane Cell wall: Peptidoglycan NAM NAG DAP Gram-positive bacteria only: Teichoic acid Lipoteichoic acid Endospore Gram-negative bacteria only: Bacterial outer membrane Porin Lipopolysaccharide Periplasmic space Mycobacteria only: Arabinogalactan Mycolic acid
Outside envelope	Bacterial capsule Slime layer S-layer Glycocalyx Pilus Fimbria Non-motile bacteria
Composite	Biofilm

Taxonomy
and evolution

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