Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase

γ-L-Glutamyl-butirosin B γ-glutamyl cyclotransferase (EC 4.3.2.6, btrG (gene)) is an enzyme with systematic name γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase (5-oxo-L-proline producing). This enzyme catalyses the following chemical reaction

γ-L-glutamyl-butirosin B

\rightleftharpoons

butirosin B + 5-oxo-L-proline

The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B.

References

Llewellyn NM, Li Y, Spencer JB (April 2007). "Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain". Chemistry & Biology. 14 (4): 379–86. doi:10.1016/j.chembiol.2007.02.005. PMID 17462573.

External links

Gamma-L-glutamyl-butirosin+B+gamma-glutamyl+cyclotransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Carbon–nitrogen lyases (EC 4.3)
4.3.1: ammonia-lyases	Histidine ammonia-lyase Formiminotransferase cyclodeaminase Serine dehydratase Phenylalanine ammonia-lyase
4.3.2: amidine-lyases	Argininosuccinate lyase Adenylosuccinate lyase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 4.3.2