Gaudencio may refer to the following people:
- Given name
- Gaudencio Hernández Burgos (born 1962), Mexican politician
- Gaudencio Rosales (born 1932), Roman Catholic Cardinal and Archbishop of Manila, the Philippines
- José Gaudencio León Castañeda (born 1960), Mexican politician
- Surname
- Miguel Gaudêncio, African-Portuguese film director
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